Poster Title

Effect of Delivery System of Photosensitizer in Photodynamic Therapy and Tumor

Institution

University of Louisville

Abstract

The effect of Photofrin photosensitizer encapsulated in liposomal delivery vehicles was studied by observing tumor response after conducting photodynamic therapy (PDT). PDT involves the administration of a tumor-localizing photosensitizing agent followed by activation of the agent by light of a specific wavelength. The therapy results in a sequence of photochemical and photobiological processes that cause irreversible damage to tumor tissue. Three liposomal delivery vehicles were chosen to deliver the photosensitizer in vivo: DDPC/cholesterol, DMPC/ HPC and stealth liposomes. Selective tumor destruction was observed with each delivery vehicle upon observation of tumor response.

This document is currently not available here.

Share

COinS
 

Effect of Delivery System of Photosensitizer in Photodynamic Therapy and Tumor

The effect of Photofrin photosensitizer encapsulated in liposomal delivery vehicles was studied by observing tumor response after conducting photodynamic therapy (PDT). PDT involves the administration of a tumor-localizing photosensitizing agent followed by activation of the agent by light of a specific wavelength. The therapy results in a sequence of photochemical and photobiological processes that cause irreversible damage to tumor tissue. Three liposomal delivery vehicles were chosen to deliver the photosensitizer in vivo: DDPC/cholesterol, DMPC/ HPC and stealth liposomes. Selective tumor destruction was observed with each delivery vehicle upon observation of tumor response.