Effect of Delivery System of Photosensitizer in Photodynamic Therapy and Tumor
Institution
University of Louisville
Faculty Advisor/ Mentor
Ronald Fell
Abstract
The effect of Photofrin photosensitizer encapsulated in liposomal delivery vehicles was studied by observing tumor response after conducting photodynamic therapy (PDT). PDT involves the administration of a tumor-localizing photosensitizing agent followed by activation of the agent by light of a specific wavelength. The therapy results in a sequence of photochemical and photobiological processes that cause irreversible damage to tumor tissue. Three liposomal delivery vehicles were chosen to deliver the photosensitizer in vivo: DDPC/cholesterol, DMPC/ HPC and stealth liposomes. Selective tumor destruction was observed with each delivery vehicle upon observation of tumor response.
Effect of Delivery System of Photosensitizer in Photodynamic Therapy and Tumor
The effect of Photofrin photosensitizer encapsulated in liposomal delivery vehicles was studied by observing tumor response after conducting photodynamic therapy (PDT). PDT involves the administration of a tumor-localizing photosensitizing agent followed by activation of the agent by light of a specific wavelength. The therapy results in a sequence of photochemical and photobiological processes that cause irreversible damage to tumor tissue. Three liposomal delivery vehicles were chosen to deliver the photosensitizer in vivo: DDPC/cholesterol, DMPC/ HPC and stealth liposomes. Selective tumor destruction was observed with each delivery vehicle upon observation of tumor response.