Northern Kentucky University

Poster Title

Effects of the Material Functionalization and the Ionic Composition of the Release Medium on the Loading and the Release of the Chemotherapeutic Agent Doxorubicin onto and from Functionalized Mesoporous Silicates

Institution

Northern Kentucky University

Abstract

When administered in high systemic doses, chemotherapeutic drugs can cause severe toxicity to the healthy tissue cells, resulting in hair loss, nausea and anemia. Drug encapsulation into delivery particulates is a way to reduce this toxicity, while allowing a high concentration of the drug to be delivered directly at the tumor site. Our ongoing research has focused on mesoporous inorganic-based silica particles as possible carriers for the anticancer agent, Doxorubicin (Dox). We already showed that mesoporous silicates functionalized with sulfonate (SO3-Na+) groups were capable of loading up to 200 mg of Dox per gram of solid and that a sustained and complete Dox release was obtained from these Dox-loaded materials. In this project, mesoporous silicates functionalized with various amounts of both sulfonate and phenyl groups were investigated for their Dox loading capacity. The incorporation of phenyl groups significantly lower the Dox loading capacity of the materials. The release profiles of Doxorubicin from Doxloaded sulfonate-functionalized material in release media of various CaCl2 concentrations (0.08 wt%, 0.17 wt%, and 0.25 wt%) were monitored by UV-Vis at 37°C. The presence of significant amounts of Ca2+ ions in the release medium seems to increase the release rate of Dox, which may be explained as two molecules of Dox in their ionic form are released for every Ca2+ ion.

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Effects of the Material Functionalization and the Ionic Composition of the Release Medium on the Loading and the Release of the Chemotherapeutic Agent Doxorubicin onto and from Functionalized Mesoporous Silicates

When administered in high systemic doses, chemotherapeutic drugs can cause severe toxicity to the healthy tissue cells, resulting in hair loss, nausea and anemia. Drug encapsulation into delivery particulates is a way to reduce this toxicity, while allowing a high concentration of the drug to be delivered directly at the tumor site. Our ongoing research has focused on mesoporous inorganic-based silica particles as possible carriers for the anticancer agent, Doxorubicin (Dox). We already showed that mesoporous silicates functionalized with sulfonate (SO3-Na+) groups were capable of loading up to 200 mg of Dox per gram of solid and that a sustained and complete Dox release was obtained from these Dox-loaded materials. In this project, mesoporous silicates functionalized with various amounts of both sulfonate and phenyl groups were investigated for their Dox loading capacity. The incorporation of phenyl groups significantly lower the Dox loading capacity of the materials. The release profiles of Doxorubicin from Doxloaded sulfonate-functionalized material in release media of various CaCl2 concentrations (0.08 wt%, 0.17 wt%, and 0.25 wt%) were monitored by UV-Vis at 37°C. The presence of significant amounts of Ca2+ ions in the release medium seems to increase the release rate of Dox, which may be explained as two molecules of Dox in their ionic form are released for every Ca2+ ion.