Western Kentucky University

Poster Title

Antimicrobial and Antiangiogenic Drugs - Relevance in Biomedical Research: Study 1 (Pender, Vangala, Badwaik, & Thompson)

Institution

Western Kentucky University

Abstract

Need for novel, innovative strategies for developing antibiotics is becoming a necessity due to an increasing number of rapidly evolving micro-organismal threats. Antibiotic encapsulated gold nanoparticles (GNPs) are one such strategy showing promise. We report the development of ampicillin encapsulated gold nanoparticles (Amp-GNPs) that possess highly effective, dose dependent antibacterial activity. Our method for synthesizing Amp-GNPs is an entirely eco-friendly, single step reaction, taking place within an aqueous buffer. We have tested the antibacterial activity of Amp-GNPs against multiple strains of bacteria, both Gram-positive and Gram-negative, and have found Amp-GNPs to be highly efficient against all tested strains. Amp-GNPs have been shown to exhibit significant potential and ability to enter the medical field’s arsenal to fight infectious disease.

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Antimicrobial and Antiangiogenic Drugs - Relevance in Biomedical Research: Study 1 (Pender, Vangala, Badwaik, & Thompson)

Need for novel, innovative strategies for developing antibiotics is becoming a necessity due to an increasing number of rapidly evolving micro-organismal threats. Antibiotic encapsulated gold nanoparticles (GNPs) are one such strategy showing promise. We report the development of ampicillin encapsulated gold nanoparticles (Amp-GNPs) that possess highly effective, dose dependent antibacterial activity. Our method for synthesizing Amp-GNPs is an entirely eco-friendly, single step reaction, taking place within an aqueous buffer. We have tested the antibacterial activity of Amp-GNPs against multiple strains of bacteria, both Gram-positive and Gram-negative, and have found Amp-GNPs to be highly efficient against all tested strains. Amp-GNPs have been shown to exhibit significant potential and ability to enter the medical field’s arsenal to fight infectious disease.