University of Louisville

Poster Title

Thrombospondin-1 Decreases NO-mediated Vasodilation in Coronary Arterioles in Advancing Age

Institution

University of Louisville

Abstract

In rat stromal vascular fraction (SVF), matricellular protein thrombospondin-1 (Thbs-1) has been shown to be upregulated with advancing age as compared to young rat SVF cells isolated from adipose tissue. Thbs-1 has been previously linked to decreased NO-mediated vasodilation in large arterial vessels, especially in diseased state. We wanted to assess this finding in smaller vessels like the coronary arterioles to determine whether there are age-related detriments of Thbs-1, as well as quantitatively asses the amount of oxygen radical production by the vessels.

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Thrombospondin-1 Decreases NO-mediated Vasodilation in Coronary Arterioles in Advancing Age

In rat stromal vascular fraction (SVF), matricellular protein thrombospondin-1 (Thbs-1) has been shown to be upregulated with advancing age as compared to young rat SVF cells isolated from adipose tissue. Thbs-1 has been previously linked to decreased NO-mediated vasodilation in large arterial vessels, especially in diseased state. We wanted to assess this finding in smaller vessels like the coronary arterioles to determine whether there are age-related detriments of Thbs-1, as well as quantitatively asses the amount of oxygen radical production by the vessels.