Title

Community Usage of Select Illicit and Prescribed Drugs and their Occurrence in the Clarks River

Academic Level at Time of Presentation

Senior

Major

Chemistry

Minor

Agriculture

List all Project Mentors & Advisor(s)

Bikram Subedi

Presentation Format

Poster Presentation

Abstract/Description

Drug abuse is considered a national epidemic in many countries including the USA and is associated with impaired socio-economic loss and adverse public health. Wastewater based epidemiology (WBE) is a cost-effective, comprehensive, and a non-invasive technique capable of determining semi-real-time community usage of drugs utilizing the concentration of drug residues in wastewater, wastewater inflow, and the population served by the centralized wastewater treatment plant. An analytical method capable of simultaneous analysis of 10 illicit drugs, 19 prescribed drugs, and their 7 metabolites was developed and validated. Wastewater influent, effluent, immediate receiving water (Bee Creek), and the Clarks River water were sampled for seven consecutive days in Murray, KY. Samples were extracted and being analyzed using liquid chromatography-triple quadrupole tandem mass spectrometer (LC‒MS/MS). The limit of quantitation of drug residues were 10 ng/L to 400 ng/L. Triplicate spiking recoveries of drug residues in wastewater and river water ranged from 58±8.3% (oxycodone) to 108±7.2% (venlafaxine).

Affiliations

General Posters Session--ONLY, Sigma Xi Poster Competition--ONLY

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Community Usage of Select Illicit and Prescribed Drugs and their Occurrence in the Clarks River

Drug abuse is considered a national epidemic in many countries including the USA and is associated with impaired socio-economic loss and adverse public health. Wastewater based epidemiology (WBE) is a cost-effective, comprehensive, and a non-invasive technique capable of determining semi-real-time community usage of drugs utilizing the concentration of drug residues in wastewater, wastewater inflow, and the population served by the centralized wastewater treatment plant. An analytical method capable of simultaneous analysis of 10 illicit drugs, 19 prescribed drugs, and their 7 metabolites was developed and validated. Wastewater influent, effluent, immediate receiving water (Bee Creek), and the Clarks River water were sampled for seven consecutive days in Murray, KY. Samples were extracted and being analyzed using liquid chromatography-triple quadrupole tandem mass spectrometer (LC‒MS/MS). The limit of quantitation of drug residues were 10 ng/L to 400 ng/L. Triplicate spiking recoveries of drug residues in wastewater and river water ranged from 58±8.3% (oxycodone) to 108±7.2% (venlafaxine).