Honors College | Session 3

Title

Tuning Recognition of Biological Anions by Modifying Anionic Recognition Group

Presenter Information

Shelby WakefieldFollow

Academic Level at Time of Presentation

Senior

Major

Chemistry

Minor

Biology

List all Project Mentors & Advisor(s)

Kasey Clear

Presentation Format

Oral Presentation

Abstract/Description

Recognizing biological phosphates and their derivatives is critical in understanding the role of these molecules in biological systems and pathways. In this work, we focused on the synthesis of two synthetic receptors that can interact with biological target molecules that possess 1,2-diols and negatively charged components such as phosphates. Both receptors included a boronic acid for 1,2-diol recognition but different anion recognition units; one receptor used guanidinium and the other used urea as the anion recognition unit. The receptors were to another structure that contained only the boronic acid. Binding and selectivity for different biological anions was measured using Alizarin Red S in an indicator displacement screening process.

Spring Scholars Week 2018 Event

Honors College Senior Thesis Presentation

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Tuning Recognition of Biological Anions by Modifying Anionic Recognition Group

Recognizing biological phosphates and their derivatives is critical in understanding the role of these molecules in biological systems and pathways. In this work, we focused on the synthesis of two synthetic receptors that can interact with biological target molecules that possess 1,2-diols and negatively charged components such as phosphates. Both receptors included a boronic acid for 1,2-diol recognition but different anion recognition units; one receptor used guanidinium and the other used urea as the anion recognition unit. The receptors were to another structure that contained only the boronic acid. Binding and selectivity for different biological anions was measured using Alizarin Red S in an indicator displacement screening process.