Elevated Community Anxiety During COVID-19 Pandemic Based on the Quantified Biomarkers of Oxidative Stress in Wastewater

Project Abstract

There was a global impact of the novel coronavirus disease (COVID-19) including bereavement, isolation, loss of income, and fear that triggered existing mental health conditions and exacerbating the existing ones. Isoprostanes are the potential biomarkers of endogenous human metabolism and proven clinically to provide the quantitative measure of systematic oxidative injury. A UPLC-MS/MS method capable of determining four biomarkers of oxidative stress (8-iso-PGF2α, 2,3-dinor-iPF2α-III, PGE2, and 5-iPF2α-VI) in wastewater was developed and validated. In raw wastewater collected from two communities in western Kentucky and Tennessee, isoprostanes were measured (31.1 to 1270 ng/L) during the first four months of the COVID-19 pandemic. The average mass loads of PGE2 and 5-iPF2α-VI in a community were significantly increased (two-tailed pp


Conference name (full, no abbreviations): American Chemical Society National Meeting

Dates: August 22-26

Sponsoring body: Environmental Chemistry Division of American Chemical Society

Conference website: https://www.acs.org/content/acs/en/meetings/acs-meetings.html

Funding Type

Travel Grant

Academic College

Jesse D. Jones College of Science, Engineering and Technology


Chemistry/Cell Biology


Bachelors of Science




Dr. Bikram Subedi

Academic College

Jesse D. Jones College of Science, Engineering and Technology

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