Western Kentucky University
One-Step Synthesis of Highly Monodispersed, Spherical Gold Nanoparticles of 10-120 nm and Applications in Chemistry and Biology
Institution
Western Kentucky University
Faculty Advisor/ Mentor
Shivendra V. Sahi; Rajalingam Dakshinamurthy
Abstract
In recent years there are significant studies going on understanding the toxicity and rational design of gold nanoparticles (GNPs) for biomedical applications. Such efforts warrant reliable and viable green synthetic methodology for GNPs with homogenous sizes and shapes, particularly sizes above 30 nm which is currently challenging. In the present study, an environmentally benign green, one-step, one-phase and efficient synthetic approach was introduced for the synthesis of catalytically effective and surface modifiable GNPs. In this approach GNPs were synthesized by using dextrose as a reducing agent and also a stabilizing agent in aqueous medium, by maintaining the nucleation and growth without the additional need of seeding process. The resulting GNPs were highly monodispersed with spherical shape in the size range of 10-120 nm. Due to the added advantages of the biologically friendly reaction medium employed in this new synthetic scheme, GNPs in the size range of 5-50 nm were simultaneously synthesized and integrated into the bacteria.
One-Step Synthesis of Highly Monodispersed, Spherical Gold Nanoparticles of 10-120 nm and Applications in Chemistry and Biology
In recent years there are significant studies going on understanding the toxicity and rational design of gold nanoparticles (GNPs) for biomedical applications. Such efforts warrant reliable and viable green synthetic methodology for GNPs with homogenous sizes and shapes, particularly sizes above 30 nm which is currently challenging. In the present study, an environmentally benign green, one-step, one-phase and efficient synthetic approach was introduced for the synthesis of catalytically effective and surface modifiable GNPs. In this approach GNPs were synthesized by using dextrose as a reducing agent and also a stabilizing agent in aqueous medium, by maintaining the nucleation and growth without the additional need of seeding process. The resulting GNPs were highly monodispersed with spherical shape in the size range of 10-120 nm. Due to the added advantages of the biologically friendly reaction medium employed in this new synthetic scheme, GNPs in the size range of 5-50 nm were simultaneously synthesized and integrated into the bacteria.