Poster Title

The Effects of Maternal Helminths on Neuroinflammation in Offspring

Grade Level at Time of Presentation

Sophomore

Major

Neuroscience

Institution

Northern Kentucky University

Department

Neuroscience/ Biology

Abstract

Developed countries have populations of citizens shown to have more incidences of autoimmunity and allergic responses. A possible reason for this increase is the absence of commensal organisms in the macro-biome of the gut. This experiment seeks to find out the anti-inflammatory effects of helminths in rat mothers on their offspring, and how they might prevent cognitive impairment caused by early-life infection. We have orally inoculated rat dams with 4 helminths or saline control. We will be assessing fear conditioning memory on a separate group of adult males. After this we will be harvesting tissue samples from pups, including brain and blood serum. Results are forthcoming.

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The Effects of Maternal Helminths on Neuroinflammation in Offspring

Developed countries have populations of citizens shown to have more incidences of autoimmunity and allergic responses. A possible reason for this increase is the absence of commensal organisms in the macro-biome of the gut. This experiment seeks to find out the anti-inflammatory effects of helminths in rat mothers on their offspring, and how they might prevent cognitive impairment caused by early-life infection. We have orally inoculated rat dams with 4 helminths or saline control. We will be assessing fear conditioning memory on a separate group of adult males. After this we will be harvesting tissue samples from pups, including brain and blood serum. Results are forthcoming.