University of Kentucky
Applications of Basic Chemistry to Everyday Life: Catalytic Dealkylation of Phosphates with Binuclear and Mononuclear Group Thirteen Compounds
Institution
University of Kentucky
Faculty Advisor/ Mentor
David Atwood
Abstract
Salen Schiff base ligands in combination with boron reagents form some unique binuclear compounds of the general formulae: L(BR'2)2 (R' = OMe, OEt, Cl, Br) with L = Salen(t Bu). These Salen ligand types have different “backbone” connections between the two imines that may be increased or decreased to bind specific targeted compounds between the two metal centers. Mononuclear boron and aluminum compounds can also be synthesized with the same R' groups. The reactivity of these bidentate and monodentate Lewis acid compounds towards the catalytic dealkylation of phosphates will be discussed. These compounds work by breaking the P-O-C bond of the phosphate ester. Since this P-O-C bond is present in chemical warfare agents: VX, Sarin, and pesticides (such as chloropyrifos), this research might be important for the detoxification of these chemicals.
Applications of Basic Chemistry to Everyday Life: Catalytic Dealkylation of Phosphates with Binuclear and Mononuclear Group Thirteen Compounds
Salen Schiff base ligands in combination with boron reagents form some unique binuclear compounds of the general formulae: L(BR'2)2 (R' = OMe, OEt, Cl, Br) with L = Salen(t Bu). These Salen ligand types have different “backbone” connections between the two imines that may be increased or decreased to bind specific targeted compounds between the two metal centers. Mononuclear boron and aluminum compounds can also be synthesized with the same R' groups. The reactivity of these bidentate and monodentate Lewis acid compounds towards the catalytic dealkylation of phosphates will be discussed. These compounds work by breaking the P-O-C bond of the phosphate ester. Since this P-O-C bond is present in chemical warfare agents: VX, Sarin, and pesticides (such as chloropyrifos), this research might be important for the detoxification of these chemicals.