Date on Honors Thesis

Fall 12-2022

Department

**Jesse D. Jones College of Science, Engineering and Technology**

Major

Bachelor of Science in Agriculture

Minor

Chemistry

Examining Committee Member

Tara Joiner, MS, LVT, Advisor

Examining Committee Member

Dr. Laura Ken Hoffman, Committee Member

Examining Committee Member

Barbie Papajeski, MS, LVT, RLATG, VTS, Committee Member

Abstract/Description

Osteoarthritis is one of the most common forms of arthritis in canines. Osteoarthritis affects the entire joint, and typically results in pain, inflammation, decreased range of motion and development of bone spurs. The purpose of this study was to provide clinical research comparing Water-Soluble Cannabidiol (CBD) and Cannabidiol (CBD) oil as an anti-inflammatory in arthritic dogs by using gait analysis on the Tekscan Strideway System, Canine Brief Pain Inventory owner surveys, and analysis of blood test results. One clinical trial was conducted with thirteen privately owned dogs. Participants were split into three treatment groups by listing them by last names and labeling them 1,2,3,1,2,3, etc. The first group was given CBD oil daily for the entirety of the 8-week clinical trial, the second group was given Water-Soluble CBD daily for the entirety of the 8-week clinical trial, and the third group was given placebo daily for the entirety of the 8-week clinical trial.

Gait analysis results did not show improvement in gait and body weight distribution in either treatment group, nor did they show that the Water-Soluble CBD had increased improvement compared to the CBD oil. Canine Brief Pain Inventory Surveys did not show significant reductions in pain severity scores and pain interference scores in the Water-Soluble CBD group and the placebo group but did show significant reduction in the CBD oil group in 4 of the 5 patients. The chemistry panel and Complete Blood Count (CBC) did not show significant overall effect on liver and kidney functions in any of the canines.

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