Water solubility structure activity relationship of chalcones for aqueous applications

Project Abstract

Chalcones are a group of synthetic and naturally occurring small molecules containing two aromatic rings separated by an α,β-unsaturated carbonyl moiety. Chalcones are a versatile motif for organic synthesis, noted for their ability to act as Michael acceptors. They are a starting place for drug development, photodynamic therapy, and for the creation of organic materials. An issue relevant to all these fields is water solubility. Therefore, this study presents a small library of hydroxymethyl chalcones appended with a variety of solubilizing groups, and the effect of those groups on water solubility of the resulting chalcones. This series of novel chalcones represents a set of new building blocks which may be useful on the road to making more specially tailored, aqueous soluble compounds for a variety of applications.

Conference

American Chemical Society National Meeting

March 26-30th

The American Chemical Society

: https://www.acs.org/meetings/acs-meetings/spring-2023.html

Funding Type

Travel Grant

Academic College

Jesse D. Jones College of Science, Engineering and Technology

Area/Major/Minor

Chemistry Polymer/Material Science

Degree

Chemistry

Classification

Senior

Name

Grace Eder, PhD

Academic College

Jesse D. Jones College of Science, Engineering and Technology

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