Project Title
Water solubility structure activity relationship of chalcones for aqueous applications
Project Abstract
Chalcones are a group of synthetic and naturally occurring small molecules containing two aromatic rings separated by an α,β-unsaturated carbonyl moiety. Chalcones are a versatile motif for organic synthesis, noted for their ability to act as Michael acceptors. They are a starting place for drug development, photodynamic therapy, and for the creation of organic materials. An issue relevant to all these fields is water solubility. Therefore, this study presents a small library of hydroxymethyl chalcones appended with a variety of solubilizing groups, and the effect of those groups on water solubility of the resulting chalcones. This series of novel chalcones represents a set of new building blocks which may be useful on the road to making more specially tailored, aqueous soluble compounds for a variety of applications.
Conference
American Chemical Society National Meeting
March 26-30th
The American Chemical Society
: https://www.acs.org/meetings/acs-meetings/spring-2023.html
Funding Type
Travel Grant
Academic College
Jesse D. Jones College of Science, Engineering and Technology
Area/Major/Minor
Chemistry Polymer/Material Science
Degree
Chemistry
Graduation Expected
May/2023
Classification
Senior
Name
Grace Eder, PhD
Academic College
Jesse D. Jones College of Science, Engineering and Technology
Beginning date of project
1-2023
End date of project
5-2023
Recommended Citation
Yocum, Grace, "Water solubility structure activity relationship of chalcones for aqueous applications" (2023). ORCA Travel & Research Grants. 133.
https://digitalcommons.murraystate.edu/orcagrants/133