Comparison of Water-Soluble CBD and CBD Oil as an Anti-Inflammatory in Canines with Osteoarthritis

Presenter Information

Sadie SimsFollow

Academic Level at Time of Presentation

Senior

Major

Bachelor of Science in Agriculture

Minor

Chemistry

List all Project Mentors & Advisor(s)

Tara Joiner, MS, LVT; Dr. Laura Ken Hoffman; Barbie Papajeski, MS, LVT, RLATG, VTS

Presentation Format

Oral Presentation

Abstract/Description

Osteoarthritis is the most common form of arthritis in dogs. It is a chronic joint disease and can occur due to genetics and secondarily to other orthopedic diseases. It is typically treated with weight maintenance, modifying activity, joint supplements, and pain control with NSAIDs (“Osteoarthritis in Dogs”, n.d.). Cannabis sativa is the plant that marijuana and hemp come from. (Kogan et al., 2016). CBD does not produce euphoria or intoxication like the main psychoactive cannabinoid, tetrahydrocannabinol (THC). THC and CBD react on different receptors and more evidence shows that CBD acts on different types of brain signaling and that that may contribute to its therapeutic effects (“The Biology and Potential Therapeutic Effects of Cannabidiol”, 2015).

There are potentially anti-inflammatory properties in CBD. There is limited evidence for treating diseases in animals with CBD but there have been pilot studies with osteoarthritis pain that provided promising results (Deabold et al., 2019).

Water-Soluble CBD is made with a nanotechnology that allows CBD to be absorbed in water rather than an oil. In the research done thus far, it shows that the body absorbs Water-Soluble CBD easier than CBD oil because the nanoparticles can enter the bloodstream and cells quicker (Clark, 2021).

The purpose of this study was to provide clinical research comparing Water-Soluble CBD and CBD oil as an anti-inflammatory in arthritic dogs by using gait analysis on the Tekscan Strideway System, Canine Brief Pain Inventory owner surveys, and analysis of blood test results. One clinical trial was conducted with thirteen privately owned dogs. Participants were split into three treatment groups by listing them by last names and labeling them 1,2,3,1,2,3, etc. The first group was given CBD oil daily for the entirety of the 8-week clinical trial, the second group was given Water-Soluble CBD daily for the entirety of the 8-week clinical trial, and the third group was given placebo daily for the entirety of the 8-week clinical trial. Results were collected and analyzed to determine that there is no significant difference between CBD oil and Water-Soluble CBD in terms of alleviating osteoarthritis symptoms in canines.

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Comparison of Water-Soluble CBD and CBD Oil as an Anti-Inflammatory in Canines with Osteoarthritis

Osteoarthritis is the most common form of arthritis in dogs. It is a chronic joint disease and can occur due to genetics and secondarily to other orthopedic diseases. It is typically treated with weight maintenance, modifying activity, joint supplements, and pain control with NSAIDs (“Osteoarthritis in Dogs”, n.d.). Cannabis sativa is the plant that marijuana and hemp come from. (Kogan et al., 2016). CBD does not produce euphoria or intoxication like the main psychoactive cannabinoid, tetrahydrocannabinol (THC). THC and CBD react on different receptors and more evidence shows that CBD acts on different types of brain signaling and that that may contribute to its therapeutic effects (“The Biology and Potential Therapeutic Effects of Cannabidiol”, 2015).

There are potentially anti-inflammatory properties in CBD. There is limited evidence for treating diseases in animals with CBD but there have been pilot studies with osteoarthritis pain that provided promising results (Deabold et al., 2019).

Water-Soluble CBD is made with a nanotechnology that allows CBD to be absorbed in water rather than an oil. In the research done thus far, it shows that the body absorbs Water-Soluble CBD easier than CBD oil because the nanoparticles can enter the bloodstream and cells quicker (Clark, 2021).

The purpose of this study was to provide clinical research comparing Water-Soluble CBD and CBD oil as an anti-inflammatory in arthritic dogs by using gait analysis on the Tekscan Strideway System, Canine Brief Pain Inventory owner surveys, and analysis of blood test results. One clinical trial was conducted with thirteen privately owned dogs. Participants were split into three treatment groups by listing them by last names and labeling them 1,2,3,1,2,3, etc. The first group was given CBD oil daily for the entirety of the 8-week clinical trial, the second group was given Water-Soluble CBD daily for the entirety of the 8-week clinical trial, and the third group was given placebo daily for the entirety of the 8-week clinical trial. Results were collected and analyzed to determine that there is no significant difference between CBD oil and Water-Soluble CBD in terms of alleviating osteoarthritis symptoms in canines.