Honors College Senior Thesis Presentations
Gli-similar 3 is essential for proper kidney development and may be important for the maintenance or formation of primary cilia
Academic Level at Time of Presentation
Senior
Major
Chemistry
Minor
Cell Biology
List all Project Mentors & Advisor(s)
Gary ZeRuth, PhD
Presentation Format
Oral Presentation
Abstract/Description
Transcription factor Glis3 is essential for proper kidney development, and may play an important role in the maintenance/formation of primary cilia. Loss of function of this gene in humans is characterized by neonatal diabetes, congenital hypothyroidism, and polycystic kidney disease. Zebrafish knockout models of the Glis3 gene have given important insight into the molecular mechanisms and pathways involved in these phenotypes, specifically with the kidney.
Spring Scholars Week 2025
Honors College Senior Thesis Presentations
Gli-similar 3 is essential for proper kidney development and may be important for the maintenance or formation of primary cilia
Transcription factor Glis3 is essential for proper kidney development, and may play an important role in the maintenance/formation of primary cilia. Loss of function of this gene in humans is characterized by neonatal diabetes, congenital hypothyroidism, and polycystic kidney disease. Zebrafish knockout models of the Glis3 gene have given important insight into the molecular mechanisms and pathways involved in these phenotypes, specifically with the kidney.
