Evaluation of Pancreatic Development in Glis3 Mutant Zebrafish
Academic Level at Time of Presentation
Senior
Major
Biology/Pre-Medicine
Minor
Chemistry and Psychology
List all Project Mentors & Advisor(s)
Dr. Gary ZeRuth
Presentation Format
Oral Presentation
Abstract/Description
Glis3 is a transcription factor indicated in the development of many human pathologies, such as neonatal diabetes, congenital hypothyroidism, polycystic kidney disease, and type II diabetes mellitus. Using zebrafish (Danio rerio) as a model organism, a knockout line was created using CRISPR/Cas9 gene editing technology. In comparing the knockout line to the wildtypes, the goal is to better understand the role(s) Glis3 plays in the maturation of the pancreas and how it can provide insights into the development of type II diabetes.
Spring Scholars Week 2026
Honors College Senior Thesis Presentations
Evaluation of Pancreatic Development in Glis3 Mutant Zebrafish
Glis3 is a transcription factor indicated in the development of many human pathologies, such as neonatal diabetes, congenital hypothyroidism, polycystic kidney disease, and type II diabetes mellitus. Using zebrafish (Danio rerio) as a model organism, a knockout line was created using CRISPR/Cas9 gene editing technology. In comparing the knockout line to the wildtypes, the goal is to better understand the role(s) Glis3 plays in the maturation of the pancreas and how it can provide insights into the development of type II diabetes.