Morehead State University
Observing Performance of Swine that Receive Equine Plasma from Horses Immunized with Modified Live Porcine Reproductive and Respiratory Syndrome Vaccine1
Institution
Morehead State University
Faculty Advisor/ Mentor
Duane Chappell
Abstract
Porcine reproductive and respiratory syndrome “PRRS” is a disease that drastically affects pregnant sows and growing piglets. Recent studies have determined that economic losses from this virus have reached $641 million dollars annually. In order to address this situation, studies have been focused on linking the inoculation period in relation to performance variance. Our objective was to observe the characteristics displayed after passive administration of equine origin PRRS antibody on humoral and cell mediated immunity. The study included two separate phases of 24 and 30 Yorkshire Cross, weanling piglets that came from a PRRS vaccinated, field virus negative herd. Each phase was inoculated with either: placebo, equine plasma from horses not immunized with PRRS vaccine, equine plasma from horses immunized with PRRS vaccine or modified live Porcine Reproductive and Respiratory Syndrome Vaccine1. Weekly intervals were used to measure the rate of growth, collect blood for serum samples and administer intradermal injection of PRRS antigen to evaluate delayed type hypersensitivity. Serum samples were assayed for PRRS antibody using Enzyme-linked Immunosorbent Assay “ELISA” for swine IgG and equine IgG. This project was funded by Mg Biologics. 1Inglevac PRRS MLV “Porcine Reproductive and Respiratory Vaccine”Boehringer Ingelheim.
Observing Performance of Swine that Receive Equine Plasma from Horses Immunized with Modified Live Porcine Reproductive and Respiratory Syndrome Vaccine1
Porcine reproductive and respiratory syndrome “PRRS” is a disease that drastically affects pregnant sows and growing piglets. Recent studies have determined that economic losses from this virus have reached $641 million dollars annually. In order to address this situation, studies have been focused on linking the inoculation period in relation to performance variance. Our objective was to observe the characteristics displayed after passive administration of equine origin PRRS antibody on humoral and cell mediated immunity. The study included two separate phases of 24 and 30 Yorkshire Cross, weanling piglets that came from a PRRS vaccinated, field virus negative herd. Each phase was inoculated with either: placebo, equine plasma from horses not immunized with PRRS vaccine, equine plasma from horses immunized with PRRS vaccine or modified live Porcine Reproductive and Respiratory Syndrome Vaccine1. Weekly intervals were used to measure the rate of growth, collect blood for serum samples and administer intradermal injection of PRRS antigen to evaluate delayed type hypersensitivity. Serum samples were assayed for PRRS antibody using Enzyme-linked Immunosorbent Assay “ELISA” for swine IgG and equine IgG. This project was funded by Mg Biologics. 1Inglevac PRRS MLV “Porcine Reproductive and Respiratory Vaccine”Boehringer Ingelheim.