University of Louisville
Thrombospondin-1 Decreases NO-mediated Vasodilation in Coronary Arterioles in Advancing Age
Institution
University of Louisville
Faculty Advisor/ Mentor
Amanda Jo LeBlanc
Abstract
In rat stromal vascular fraction (SVF), matricellular protein thrombospondin-1 (Thbs-1) has been shown to be upregulated with advancing age as compared to young rat SVF cells isolated from adipose tissue. Thbs-1 has been previously linked to decreased NO-mediated vasodilation in large arterial vessels, especially in diseased state. We wanted to assess this finding in smaller vessels like the coronary arterioles to determine whether there are age-related detriments of Thbs-1, as well as quantitatively asses the amount of oxygen radical production by the vessels.
Thrombospondin-1 Decreases NO-mediated Vasodilation in Coronary Arterioles in Advancing Age
In rat stromal vascular fraction (SVF), matricellular protein thrombospondin-1 (Thbs-1) has been shown to be upregulated with advancing age as compared to young rat SVF cells isolated from adipose tissue. Thbs-1 has been previously linked to decreased NO-mediated vasodilation in large arterial vessels, especially in diseased state. We wanted to assess this finding in smaller vessels like the coronary arterioles to determine whether there are age-related detriments of Thbs-1, as well as quantitatively asses the amount of oxygen radical production by the vessels.